414 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study demonstrates that the newly synthesized organotin(IV) dithiocarbamate DioSn-2 exhibits potent and selective cytotoxicity against A549 lung cancer cells by inducing mitochondria-mediated apoptosis through oxidative stress and caspase-9 activation, positioning it as a promising alternative to cisplatin.
This study identifies the sodium-bicarbonate cotransporter NBCn1 as a critical ciliary membrane component that interacts with DYNLL1 to regulate ciliary length and SUFU localization, thereby controlling Sonic hedgehog signaling.
This study reveals that the ribosomal protein paralog Rpl12b specifically regulates TORC1 signaling and Stm1 expression to control ribosome stability, stress adaptation, and cellular longevity in *Saccharomyces cerevisiae*.
By combining CRISPR-Cas9 gene editing with live-cell imaging and proximity labeling, this study reveals that GGAs localize to distinct Golgi and peripheral compartments where they independently recruit clathrin and regulate AP-1-dependent trafficking by preventing premature AP-1 binding to its cargo, thereby modulating bi-directional transport between the Golgi and endosomes.
This study demonstrates that the interplay between the severing enzyme katanin, minus-end stabilizers CAMSAPs and WDR47, and the depolymerase kinesin-13 fine-tunes microtubule minus-end stability and abundance through a concentration-dependent balance of amplification and disassembly.
The paper introduces Brieflow, an integrated computational pipeline for high-throughput analysis of optical pooled screening data, coupled with the MozzareLLM framework for LLM-driven biological interpretation, to overcome existing analytical challenges and uncover novel biological modules such as core mitochondrial sub-programs.
This paper provides a comprehensive characterization of the immortalized human neural stem cell line HNSC.100, validating its expression of key markers, its ability to differentiate into major neural cell types, and its genetic manipulability, while offering extensive RNA expression data and a curated list of neural disorder-related genes to establish it as a versatile and robust model for neurobiological research.
This study employs a reaction-diffusion model to demonstrate that the geometry of large embryonic cells and localized nuclear activation shape distinct cytoplasmic Cdk1 waves, which subsequently drive cortical contractility by regulating Rho-actin dynamics through Ect2 inhibition.
This study reveals that gain-of-function STING1 mutations in SAVI patients drive pulmonary fibrosis by triggering a non-canonical cGAS-STING-STAT3 signaling axis that induces endothelial-to-mesenchymal transition through SLUG activation and epigenetic silencing of SOX18, independent of TGF-beta.
This study reveals that DNA damage triggers the conserved phosphorylation of Hsp70 at threonine 495, which locks the chaperone in an open conformation to regulate G1/S cell cycle progression and delay division until repair is complete.